On October 18th 2016 at 01:19:31 PM +UTC block 2463000 was mined by MiningPoolHub.
2 Blocks later, this transaction was confirmed, making it the first TX following the Tangerine whistle hard-fork. Both preceding blocks confirmed no transactions.
[The Tangerine Whistle fork](https://blog.ethereum.org/2016/10/18/faq-upcoming-ethereum-hard-fork/) was the first response to the denial of service (DoS) attacks on the Ethereum network that took place on September/October 2016.